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He mentioned on his report that the two flex tutor slots are Needle and Explosives, so probably start with there.

I play mono red, so my Karn package always includes:
1 Ensnaring Bridge
1...

Why the 1/1 split between Relic and Crypt? I like playing two Crypts, one as wish target and the other as a tutor/engineer target vs. SnT.

I doubt Goblin Engineer would replace Goblin Welder. Goblin Welder is better on curve, and does not require mana for activation. Also, you can bait Welder activation, forcing your opponent to use...

What about SoLaS? Gives life gain, protection from Plow/Push, and regrowth creatures that were countered/discarded/milled/looted.

I'm playing your list, but with Ballista in the 3rd Pyroclasm slot, as part of the Wishboard. I like have access to both Lavaman/Ballista in the 75. The trade off is the efficiency of Pyroclasm vs....