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Wrong! New fuse ruling: CMC in this case will be three, hence chalice is not a problem IF there also is an enchantment you can target and IF you have three mana at the ready

Sorry for the stupid question but how are you able to kill turn one? The only card that is able to deal damage without passing the turn is brutality and there you can choose the lifeloss mode only...

It is better against chalice on its own as well because most opponents will set CotV to one...

You just have to target yourself :-)