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Probably Serra Avenger. Now the deck has a good number of 2-drops and Vial is aimed at 3, why do we still play her?

I would play 4x Birds, and cut Avenger or Grunt.

Plains > Windswept Heath, Mishra's Factory > Ghost Quarter. I'd suggest trade Heaths for a Karakas, or cut Karakas and Mangaras altogether.

Would anyone consider playing Mental Misstep in DnT?

I tested a handful of games against UGr NO (with 4 MMS) and it feels 4-6 in their favor. I lost each time Progenitus came down as the deck is...