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sometimes you don't have a red source, the ability to not draw the card, or the need to block because you can't win without making it to the next turn. They also Sac/block Emrakul. Can't think of...

Island Sanctuary reads,

"If you would draw a card during your draw step, instead you may skip that draw. If you do, until your next turn, you can't be attacked except by creatures with flying...