As for sweepers, the best one imo Dead of Winter. You use edict effects to counter cheated creatures anyway.
I like Illness in the Ranks as it castrates Monastery Mentor, Young Pyromancer and Empty the Warrens, all 3 are in top tier decks. Against delver night of souls' betrayal is the ultimate, but also nearly impossible to resolve. For the mana I want The Abyss. I think these are all the options:
Dread of night
the abyss
illness in the ranks
Night of Souls' Betrayal
Engineered Plague
Plague Engineer
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