I would just like to note that this is a terrible plan with no reasonable justification. Yes, you could hit Engineered Plague and yes you could name Human and yes that would kill Dark Confidant, but then again, it's a one-of and if you windmill down an Engineered Plague it doesn't matter what the hell you've drawn, you win the war. Dark Confidant is remarkably good to the point where he is even relevant even in match-ups against Burn where losing life would ordinarily be counterintuitive. Any reason you could possibly come up with for cutting Dark Confidant is not a reasonable one, and this isn't even close to being one of the better bad reasons.
Assuming we're going off something relatively similar to your last posted list
here (ie: no goyf similar core), there are quite a few different things you can and should do. However, strictly with regards to Dark Confidant, Nihil Spellbomb is a waste of slots. If it's your only option to delay a Treasure Cruise, sure, toss it in. I am in a few lists, though I find Relic is better since it can single-handedly shut down any Treasure Cruises beyond the first. But you have two Oozes mainboard, Gaddock Teegs, and a whole lot of discard that has dick and less to do after a while. In short, it's an investment that makes your deck inconsistent without returns other than overkill. I would even go as far to say that a Wasteland could come out for a Dark Confidant.