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I wholeheartedly disagree about Leyline of Sanctity's inclusion; for me, it's an auto-include. Burn is cold against it, Combo has to get rid of it first, Words of War can't get you via. Enchantress, Wheel of Sun and Moon doesn't target you, no opponent's discard gets through, Zoo can't bolt your face, Tormod's Crypt targets a player, no opposing Diabolic Edict, no Siege Gang Commander usefulness against your face, no Jace the Mindsculptor screwing up your draws, etc. I'd say it's pretty decent.
When I come up with more, I'll let you know.
I'm not sure I agree with this. Yes, burn is cold against it, and yes, it's pretty good against combo. It's also good against opposing Rock decks (especially if they run Bojuka Bog/Diabolic Edict). But you wouldn't side it in against Enchantress; if they have an active Words of War, then that means they have the potential to draw a ton of cards per turn, and should have no problem finding an O-Ring to get rid of Leyline. Or they'll just kill you with Sigil of the Empty Throne. I also wouldn't side it in against opposing Wheel of Sun and Moon/Tormod's Crypt, since you pretty much don't care about graveyard hate anyway. Against Zoo, sure it keeps burn from hitting your face, but that burn can still hit your creatures, making Leyline card disadvantage for you. And they can always just Pridemage it away if they need to. I also wouldn't side it in against Goblins, since only half-nullifying Siege-Gang's fling ability isn't worth a slot to me. Same with Jace: even if he can't fateseal you, he can still Brainstorm you out of the game. You still have to deal with Jace even with Leyline out. So pretty much the only two decks I would side it in against are combo and the mirror (and burn, but that's not too prevalent). That might be enough to merit a 4-of in the sideboard, but it's definitely not an auto-include.