I'm thinking, maybe the best option for this deck is to a Stax route (minus the Chalice of the Void).
Something akin to...
10 Swamp
2 Urborg, Tomb of Yawgmoth
4 Ancient Tomb
4 City of Traitors
4 Dark Ritual
4 Thoughtseize
// The four synergic cards that are the reason to play this deck.
4 Necrogen Mists
4 Ensnaring Bridge
4 Uba Mask
4 Noetic Scales
4 The Rack
4 Powder Keg
4 Trinisphere
4 Mind Shatter/Mindscrew/Mind Rot/Mind Twist/Persecute/Profane Command
Uba Mask is fantastic. It combos with Ensnaring Bridge or Noetic Scales to lock your opponent's creatures out. Necrogen Mists likewise works well with all of those cards. It also prevents all instants, countermagic and other shenanigans that Stax had never been able to use and was always vulnerable to.
Alternatively, the deck could play Chalice and maybe Chains of the Mephistopheles but it would have to cut The Rack, Quest, Dark Ritual and Thoughtseize and use Sorin Markov and maybe Megrim for the combo. The problem is that Uba Mask isn't great with Megrim.
Or maybe the deck should through the Contagion combo in their as well along with Crucible of Worlds, Wasteland, Mishra's Factory, Mox Diamond and Smokestack.
I wanted to quote a very good suggestion for the deck which gave me the idea for Uba Mask.
I agree with you on Quest. I could easily see myself cutting it and playing Phyrexian Totem instead if I ever decide to cut Ensnaring Bridge and just count on Noetic Scales for the lock.
Uba Mask an awesome suggestion. It actually makes only 4 copies of Necrogen Mists/Oppression neccesary.
Also, what do you think is better in a deck like this,
Bottomless PitorNecrogen MistsorOppression
You only need one of those three when you're playing Uba Mask imo. Bottomless Pit is more disruptive. Mists is more consistent. But Oppression is more one sided (it affects your opponents (esp with all the Brainstorms running around) more than it does you).