Depends on the matchup, board state, cards in opponents hand, and if you have some number of dorks in your hand to deploy. More often than not, a successful surgical extraction on depths dooms your chances of winning that game. I dont know if that warrants a dedicated sideboard strategy though. To even get to the point where surgical beats you, your opponent must either dispatch Marit Lage after you've comboed, or destroy depths before you can combo (not including corner cases like getting hymned for simplicity's sake). The destroying depths before combo situation can be prevented with tight play and not exposing it prematurely. The dispatching marit lage situation can be prevented with patience and using your discard and protection spells to out-tempo your opponent. If anything, that surgical extraction is one less card that can answer the combo.
Surgical schmurgical, it doesnt matter if the guy is dead. Punish that guy for playing stupid magic cards.
Current Depths List: http://tappedout.net/mtg-decks/bg-hexmage-depths/
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