O-Stone kills MUD (one of our terrible match-ups game 1), and is an out against SnT decks because it kills Emrakul as well. It also kills Helm of Obedience.
Its weakness to Abrupt Decay is easily remedied by activating it the turn it comes into play, or if you have to play it early, by providing a good Abrupt Decay target to your opponent as bait (Most players start getting nervous when I play a Candelabra, for example).
If your local meta doesn't run a lot of Emrakuls and Helms, then All is Dust is probably better.
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