An Affinity player doesn't need to run terrible answers to terrible cards run against them. Needle is unreliable, since it doesn't actually kill anything and if the Affinity player runs Arcbound Ravager, they can respond to a late Needle. Infest is the best card a Smallpox player can run against Affinity because it punishes the very Zerg-rush strategy that Affinity uses to beat Smallpox decks. Null Rod is technically the best card against Affinity, but Infest gets the nod since it's actually relevant against other decks.
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