Getting through Chalice is a relevant consideration when discussing fair decks because odds are that sooner or later you're going to cast a Chalice, and then exactly how effective are those Deathrite Shamans and Lightning Bolts? But Thoughtseize isn't meant to go in against fair decks. It can go in against fair decks, but if it becomes a commonplace action you're doing it wrong. It's mean to go in against unfair decks. Decks that we otherwise have very little interaction with. Because it's all fine and well to say "well, Chalice at 1 stops X deck", but the trouble is living long enough or having room enough to make that a reality. When you sit down against Storm or Reanimator or whatever other unfair and oppressive pile of garbage and you look at your hand of two-drops with no Mox Diamond, the first thing that crosses your mind will always be "how the fuck am I living long enough", and Thoughtseize is your answer to that.
Thoughtseize won't win the game, which is why I don't advocate running too many copies, but it will buy you time enough to land something that can.
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